Women carrying breast cancer genes also have a low fertility

Women carrying breast cancer genes also have a low fertility
Women with a specific gene mutation that is known to increase the breast cancer risk may also have fewer eggs in their ovaries, finds significant research.

The team found that women with BRCA1 mutations had 25 percent lower AMH concentrations than non-carriers on average, which is equivalent of a two-year age increase for a non-carrier woman in her 30s. Also, BRCA1 mutation was found to damage DNA. The team said the BRCA1 mutation might stop DNA being properly repaired, which increases the risk of both cancer and infertility. The findings also raise the hypothesis that BRCA1 mutations carriers may have a higher than average risk of chemotherapy-induced menopause. For the results, the team analysed 693 women aged 25 to 45 who had no personal history of cancer. A total of 172 women were carriers and 216 women non-carriers from families carrying the BRCA1 mutations, and 147 carriers and 158 non-carriers were from families with the BRCA2 mutations. (Read: 7 foods to boost fertility in men and women)

Source: IANS

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